Water → HCID 86585576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-8-acetyl-7,8-dihydro-3-(5-methanesulfonyloxyhexyl)-1-methyl-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (560 mg, 1.28 mmol) and sodium azide (416 mg, 6.4 mmol) in dimethylsulfoxide (5 ml) was stirred at 65° C. for 7 hours. After cooling to room temperature, the reaction mixture was treated with water. After stirring for 1 hour, the solid was filtered, washed with water, and dried under vacuum to provide (R)-8-acetyl-3-(5-azidohexyl)-7,8-dihydro-1-methyl-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (395 mg, 84% yield) as a white powder.

Provenance & Evidence