Chlorosuccinimide → Aminothiazole 20

HRID 1355491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1355491
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[S:9][CH:10]=[CH:11][N:12]=1.[Cl:13]N1C(=O)CCC1=O>>[Cl:13][C:10]1[S:9][C:8]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[N:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 31398ChlorosuccinimideHCID 956683N-(pyridin-2-yl)thiazol-2-amine

Produkt 1

HCID 5329401Aminothiazole 20

Versuchsvorschrift

Pyridin-2-yl-thiazol-2-yl-amine (5-2) and 1.2 equivalents of N-chlorosuccinimide were combined in a flame dried flask and allowed to stir together overnight under argon in anhydrous dioxane (0.25 M). The dioxane solution was then diluted with water and the resulting product filtered off. 1H-NMR (DMSO-d6) δ 11.463 (1H, s) 8.30 (dd, 1H, J=4.9, 0.9 Hz) 7.73 (t, 1H, J=8.42 Hz) 7.38 (s, 1H) 7.03 (d, 1H, J=8.4 Hz) 6.96 (t, 1H, J=5.9 Hz). MS [M+H]+=211.9.

Aufarbeitung

  1. customdried flask
  2. additionThe dioxane solution was then diluted with water
  3. filtrationthe resulting product filtered off

Quellen und Nachweise

ORD-Eintrag
ord-8b6b552b634547dbaa2a411196a199fa
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586424B2

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