참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 5-bromo-N-(pyridin-2-yl)thiazol-2-amine | HCID 5329400 | — |
| 생성물 | N-(5-Bromo-thiazol-2-yl)-N-pyridin-2-yl-acetamide | HCID 18506782 | — |
반응 단계
To a flask containing (5-Bromo-thiazol-2-yl)-pyridin-2-yl-amine (5-4, 4.58 g, 17.9 mmol was added 30 mL acetic anhydride. The suspension was then heated to 100° C. After about 1.5 hours, the acetic anhydride and acetic acid was removed under reduced pressure, heating the bath to 70° C. Two 70 mL portions of toluene were also added for azeotropic distillation. The product was obtained as a tan colored precipitate. 1H NMR (DMSO-d6): δ 8.65 (d, 1H, J=3.9 Hz), 8.09 (t, 1H, J=8.6 Hz), 7.67 (d, 1H, J=8 Hz), 7.59 (t, 1H, J=6.6 Hz), 7.47 (s, 1H). mp 132-138° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06586424B2 |
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| 출처 데이터셋 | uspto-grants-2003_07 |
|---|
| ORD ID | ord-b1a73229a4ee483f85bd52dab64b3c0a |
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| 출처 메모 | uspto-grants-2003_07 |
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