反应详情

A solution of tert-butyl(1R)-1-(4,5-dimethyl-1,3-oxazol-2-yl)-2-(1H-indol-3-yl)ethylcarbamate (3 g, 8.4 mmol) in HCl/AcOEt 1N (80 ml) was stirred at room temperature for about 2.5 hours. The mixture was concentrated under reduced pressure, diethyl ether (100 ml) added, and the white precipitate collected by filtration, and washed with diethyl ether to afford the hydrochloride salt of the desired product (2.4 g). Melting point: 172-174° C.

1. concentrationThe mixture was concentrated under reduced pressure, diethyl ether (100 ml)
2. additionadded
3. filtrationthe white precipitate collected by filtration
4. washwashed with diethyl ether