HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Guanidine Nitrate | HCID 10481 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chlorobenzoylacetonitrile | HCID 138308 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Carbon Disulfide | HCID 6348 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile | HCID 4138844 | — |
Reaction Steps
From 4-chlorobenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 278 (M{37Cl}+, 14), 277 ([M{37Cl}—H]+, 42), 276 (M{35Cl} +, 46), 275 ([M{35Cl}—H]+, 100), 241 ([M—Cl]+, 30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-709d3ddd72b44eba933f13289e622e6d |
| Source note | uspto-grants-2003_07 |