HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 5-Pyrimidinecarbonitrile, 2-amino-4-(1,3-benzodioxol-5-yl)-6-(methylthio)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Guanidine Nitrate | HCID 10481 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(2H-1,3-Benzodioxol-5-yl)-3-oxopropanenitrile | HCID 19616538 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Carbon Disulfide | HCID 6348 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 5-Pyrimidinecarbonitrile, 2-amino-4-(1,3-benzodioxol-5-yl)-6-(methylthio)- | HCID 18507300 | — |
Reaction Steps
From 3-benzo[1,3]dioxol-5-yl-3-oxo-propionitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%):286 (M+, 96), 285 ([M—H]+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-f949db601a094752ac13f823f030f5f5 |
| Source note | uspto-grants-2003_07 |