Sodium Carbonate → HCID 18507227, compound

HRID 1355810Notes

Reaction equation

HRID 1355810 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.[CH:17](/B(O)O)=[CH:18]\[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd]>[NH2:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]([C:9]#[N:10])=[C:6](/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:7]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 5702628Styrylboronic acidHCID 18507370HCID 18507370, compound

Product 1

HCID 18507227HCID 18507227, compound

Reagents, catalysts & solvents 2

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

From 2-amino-4-chloro-6-phenyl-pyrimidine-5-carbonitrile, (E)-styrylboronic acid, tetrakis(triphenylphosphine)palladium(O) and sodium carbonate in dioxane/water. EI-MIS m/e (%): 298 (M+, 84), 297 ([M—H]+, 100).

Sources & evidence

ORD record
ord-d5bcada89d8a4ab4bb06e6cfd4103877
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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