Acrylonitrile → HCID 18507509, compound

HRID 1355837Notes

Reaction equation

HRID 1355837 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11](I)=[CH:10][N:9]=[C:8]([NH2:13])[N:7]=1.[C:14](#[N:17])[CH:15]=[CH2:16].C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH2:13][C:8]1[N:7]=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[C:11](/[CH:16]=[CH:15]/[C:14]#[N:17])=[CH:10][N:9]=1

Participants

6

Reactant 3

HCID 7855AcrylonitrileHCID 10796Cesium carbonateHCID 18507226HCID 18507226, compound

Product 1

HCID 18507509HCID 18507509, compound

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

From 4-furan-2-yl-5-iodo-pyrimidin-2-ylamine, acrylonitrile, bis(triphenyl-phosphine)palladium(II) chloride and cesium carbonate in dioxane. EI-MS m/e (%): 212 (M+, 52), 195 ([M—NH3]+, 100), 184 (32), 158 (52).

Sources & evidence

ORD record
ord-6ee24f5ff52541c5bd413f292158e6d2
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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