Benzylamine → 2-Amino-4-benzylamino-6-(3-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

HRID 1355887Notes

Reaction equation

HRID 1355887 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][C:12]=2[CH3:13])[C:5]([C:14]#[N:15])=[C:4](SC)[N:3]=1.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([NH:25][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:5]([C:14]#[N:15])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][C:12]=2[CH3:13])[N:7]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 185075832-Amino-4-(3-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

Product 1

HCID 185075762-Amino-4-benzylamino-6-(3-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-(3-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile and benzylamine in DME. EI-MS m/e (%): 305 (M+, 40), 304 ([M—H]+, 100).

Sources & evidence

ORD record
ord-9e038cffb268487ea89155d9b33fbb6b
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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