HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → (RS)-2-Amino-4-(5-methyl-furan-2-yl)-6-(1-pyridin-2-yl-ethoxy)-pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | alpha-Methyl-2-pyridinemethanol | HCID 86784 | — |
| Reactant | 2-Amino-4-(5-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile | HCID 18507308 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | (RS)-2-Amino-4-(5-methyl-furan-2-yl)-6-(1-pyridin-2-yl-ethoxy)-pyrimidine-5-carbonitrile | HCID 18507696 | — |
Reaction Steps
From 2-amino-4-(5-methyl-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile, (RS)-alpha-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 344 (M+Na+, 20), 322 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-059128fbeead4bf7b9d8f331faa308d2 |
| Source note | uspto-grants-2003_07 |