1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-furan-2-yl-6-(6-methyl-pyridin-3-yl-methoxy)-pyrimidine-5-carbonitrile

HRID 1356049노트

반응식

HRID 1356049 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.Cl.[CH3:19][C:20]1[N:25]=[CH:24][C:23]([CH2:26][OH:27])=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:27][CH2:26][C:23]2[CH:24]=[N:25][C:20]([CH3:19])=[CH:21][CH:22]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507531(6-Methylpyridin-3-yl)methanol hydrochlorideHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

생성물 1

HCID 185074882-Amino-4-furan-2-yl-6-(6-methyl-pyridin-3-yl-methoxy)-pyrimidine-5-carbonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, (6-methyl-pyridin-3-yl)-methanol hydrochloride and DBU in DME. ES-MS m/e (%): 308 (M+H+, 100).

출처 및 근거

ORD 기록
ord-707234d001dd464f822c3fc176a2eaf6
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

반응 노트

불러오는 중…