Water → HCID 18507480, compound

Participants

Reaction Steps

To a stirred suspension of 1.00 g (4.03 mmol) 2-amino-4-methanesulfinyl-6-thiophen-2-yl-pyrimidine-5-carbonitrile in 30 ml DME were added 1.48 g (8.06 mmol) 4-isopropenyl-benzylamine hydrochloride and 1.50 ml (10.1 mmol) DBU and stirring continued for 16 hours at room temperature. 100 ml water was then added and the resulting crystals collected by filtration to afford 200 mg (15%) 2-amino-4-furan-2-yl-6-(4-isopropenyl-benzylamino)-pyrimidine-5-carbonitrile as a white crystalline solid. ES-MS m/e (%): 332 (M+H+, 100).

Provenance & Evidence