3-Pyridinemethanamine → 2-Amino-4-furan-2-yl-6-[(pyridin-3-ylmethyl)-amino]-pyrimidine-5-carbonitrile

HRID 1356055Notes

Reaction equation

HRID 1356055 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH2:25])[CH:19]=1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([NH:25][CH2:24][C:20]2[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=2)[N:3]=1

Participants

4

Reactant 2

HCID 310183-PyridinemethanamineHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

Product 1

HCID 185077092-Amino-4-furan-2-yl-6-[(pyridin-3-ylmethyl)-amino]-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile and 3-picolylamine in DME. ES-MS m/e (%): 293 (M+H+, 100).

Sources & evidence

ORD record
ord-37f75114f2c346e09a46f3fd1084af13
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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