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HRID 1356082作成日：2026年10月26日

(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine → 2-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

https://huagongshe.com/reaction/1356082

反応式

関与物質

役割名称HCID仕込み量
反応物(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamineHCID 11085087—
反応物2-Amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrileHCID 18507560—
溶媒1,2-DimethoxyethaneHCID 8071—
生成物2-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrileHCID 18507413—

反応手順

From 2-amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile and 2-aminomethyl-3-chloro-5-(trifluoromethyl)pyridine in DME. ES-MS m/e (%): 411 (M{37Cl}+H+, 35), 409 (M{35Cl}+H+, 100).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06586441B2
出典データセットuspto-grants-2003_07
ORD IDord-a2007de0610d4081a4345793430aade1
出典メモuspto-grants-2003_07