HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 2-Amino-4-(5,6-dihydro-4H-pyran-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Tributyltin Chloride | HCID 15096 | — |
| Reactant | 2-Amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile | HCID 18753230 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-4-(5,6-dihydro-4H-pyran-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile | HCID 18507318 | — |
Reaction Steps
From 3,4-dihydro-2H-pyran, tert-butyllithium and tributyltin chloride in THF. Then treatment with 2-amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile and bis(triphenylphosphine)palladium(II) chloride in dioxane. ES-MS m/e (%): 271 (M+Na+, 39), 249 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-7723afc591ce4d99b29b53b48d55fed9 |
| Source note | uspto-grants-2003_07 |