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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1356112Generated: October 31, 2026

1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(3-methyl-pyridin-2-ylmethoxy)-6-pyridin-2-yl-pyrimidine-5-carbonitrile

https://huagongshe.com/reaction/1356112

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
Reactant(3-Methylpyridin-2-yl)methanolHCID 1514369—
Reactant2-Amino-4-methanesulfinyl-6-pyridin-2-yl-pyrimidine-5-carbonitrileHCID 18507695—
Solvent1,2-DimethoxyethaneHCID 8071—
Product2-Amino-4-(3-methyl-pyridin-2-ylmethoxy)-6-pyridin-2-yl-pyrimidine-5-carbonitrileHCID 18507214—

Reaction Steps

From 2-amino-4-methanesulfinyl-6-pyridin-2-yl-pyrimidine-5-carbonitrile, 3-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 319 (M+H+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06586441B2
Source datasetuspto-grants-2003_07
ORD IDord-c1f74d0a6c9443fd9f2dfe092f19f6a0
Source noteuspto-grants-2003_07