4-(Trifluoromethyl)benzylamine → 2-Amino-4-(4,5-dihydro-furan-2-yl)-6-(4-trifluoromethyl-benzylamino)-pyrimidine-5-carbonitrile

HRID 1356124Notes

Reaction equation

HRID 1356124 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](OS(C(F)(F)F)(=O)=O)[C:5]([C:16]#[N:17])=[C:4]([C:18]2[O:19][CH2:20][CH2:21][CH:22]=2)[N:3]=1.[F:23][C:24]([F:34])([F:33])[C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH2:30])=[CH:27][CH:26]=1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([C:18]2[O:19][CH2:20][CH2:21][CH:22]=2)[C:5]([C:16]#[N:17])=[C:6]([NH:30][CH2:29][C:28]2[CH:27]=[CH:26][C:25]([C:24]([F:23])([F:33])[F:34])=[CH:32][CH:31]=2)[N:7]=1

Participants

4

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 86583757Trifluoromethanesulfonic acid 2-amino-5-cyano-6-(4,5-dihydro-furan-2-yl)-pyrimidin-4-yl ester

Product 1

HCID 185076622-Amino-4-(4,5-dihydro-furan-2-yl)-6-(4-trifluoromethyl-benzylamino)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From trifluoromethanesulfonic acid 2-amino-5-cyano-6-(4,5-dihydro-furan-2-yl)-pyrimidin-4-yl ester and 4-trifluoromethylbenzylamine in DME. ES-MS m/e (%): 362 (M+H+, 100).

Sources & evidence

ORD record
ord-35f01642f8ed4aa29379256375b6fb37
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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