Chlorosuccinimide → HCID 18507205, compound

Participants

Reaction Steps

To a stirred solution of 2.03 g (8.73 mmol) 2-amino-4-furan-2-yl-6-methylsulfanyl-pyrimidine-5-carbonitrile in 12 ml DMF was added 1.22 g (9.16 mmol) N-chlorosuccinimide and stirring continued at 50° C. for 2 hours. The reaction mixture was then poured into 500 ml ice-water and the resulting precipitate collected by filtration and washed with water and then ether to afford 2.19 g (94%) 2-amino-4-(5-chloro-furan-2-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile as a light brown crystalline solid. EI-MS m/e (%): 268 (M{37Cl}+, 22), 267 ([M{37Cl}-H]+, 42), 266 (M{35Cl}+, 64), 265 ([M{35Cl}-H]+, 100), 231 ([M—Cl]+, 37).

Provenance & Evidence