HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(4-bromo-furan-2-yl)-6-(3,5-dimethyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | (3,5-Dimethylpyridin-2-yl)methanol | HCID 10630548 | — |
| Reactant | 2-Amino-4-(4-bromo-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile | HCID 18507498 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 2-Amino-4-(4-bromo-furan-2-yl)-6-(3,5-dimethyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile | HCID 18507415 | — |
Reaction Steps
From 2-amino-4-(4-bromo-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile, 3,5-dimethyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 402 (M{81Br}+H+, 100), 400 (M{79Br}+H+, 95).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586441B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-b30c88b3146b46099e0477e87ec1ad41 |
| Source note | uspto-grants-2003_07 |