Potassium Carbonate → HCID 12069132, compound

Participants

Reaction Steps

5-((2S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-hydroxy-benzoic acid methyl ester of Step C (213 mg, 0.49 mmol) is stirred in acetone (2 mL) with powdered K2CO3 (207 mg, 1.5 mmol) and bromomethyl acetate (95uL, 1.5 mmol) at RT under N2 and then at 50° C. The reaction is diluted with EtOAc (100 mL) and washed with 1N HCl (30 mL) and saturated NaHCO3 (2×30 mL). The organics are dried (MgSO4), filtered, concentrated and purified by flash column chromatography to provide 5-((2S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxycarbonylmethoxy-benzoic acid methyl ester.

Provenance & Evidence