HCID 12069132, compound → HCID 12069133, compound

Participants

Reaction Steps

5-((2S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxycarbonylmethoxy-benzoic acid methyl ester of Step D (135 mg, 0.27 mmol) is stirred in 95% EtOH (3 mL) with Pearlman's catalyst (palladium hydroxide on carbon) (70 mg) and put through a vacuum/purge cycle 3 times with H2 gas. The reaction is then held under 1 atm of H2 overnight. The catalyst is then filtered off on GF/F filter paper and the filtrate concentrated to provide 5-((2S)-2-tert-butoxycarbonylamino-2-carboxy-ethyl)-2-methoxycarbonylmethoxy-benzoic acid methyl ester which is used without further purification.

Provenance & Evidence