Dichloromethane → 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 135624Notes

Reaction equation

HRID 135624 reaction equation
[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][OH:11])[CH2:2][CH2:3]1.[Cl:26][CH2:27][Cl:28].[S:22]([Cl:23])([Cl:24])=[O:25]>>[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][Cl:24])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 21935648HCID 21935648, compound

Product 1

HCID 219359605-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Sources & evidence

ORD record
ord-5c2efabbadb441e7ad706701fa49dd20
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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