反应详情

A chilled (0° C. ) mixture of tert-butyl 6-(2-ethoxy-2-oxoethyl)-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate in tetrahydrofuran (30 mL) was treated over 1 h with 1 M diisobutylaluminum hydride (19.0 mL, 19.0 mmol) in dichloromethane. After 1.5 h, ice was added and the mixture was allowed to warm to rt. The mixture was evaporated in vacuo and the residue was partitioned between ethyl acetate and water. The organic phase was filtered through celite, dried, and evaporated in vacuo to provide 2.479 g of the title compound, the structure of which is shown in FIG. 6 as (24) (where n=1).

1. temperatureA chilled
2. additionice was added
3. customThe mixture was evaporated in vacuo
4. customthe residue was partitioned between ethyl acetate and water
5. filtrationThe organic phase was filtered through celite
6. customdried
7. customevaporated in vacuo