HCID 22396595, compound → HCID 69894563, compound

HRID 1356378Notes

Reaction equation

HRID 1356378 reaction equation
Cl.Cl.ClC1C=CC(C2C3C4CCNCCC4NC=3C=CC=2)=CC=1.[CH:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][C:25]=1[O:34][CH2:35][CH2:36][CH2:37][C:38]1[C:39]2[C:40]3[CH2:51][CH2:50][NH:49][CH2:48][CH2:47][C:41]=3[NH:42][C:43]=2[CH:44]=[CH:45][CH:46]=1>>[CH:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][C:25]=1[O:34][CH2:35][CH2:36][CH2:37][C:38]1[C:39]2[C@@H:40]3[CH2:51][CH2:50][NH:49][CH2:48][CH2:47][C@@H:41]3[NH:42][C:43]=2[CH:44]=[CH:45][CH:46]=1

Participants

3

Reactant 2

HCID 22396595HCID 22396595, compoundHCID 22609212HCID 22609212, compound

Product 1

HCID 69894563HCID 69894563, compound

Procedure

Following the procedure for the preparation of 10-(4-chlorophenyl)-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole dihydrochloride, making non-critical variations, starting from 10-[3-(2-naphthyloxy)propyl]-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole the title compound was prepared: 1H NMR (CDCl3) δ 1.89-2.08, 2.22, 2.77, 2.91, 3.07, 3.26, 3.51, 3.67, 4.14, 6.47, 6.64, 7.05, 7.12, 7.16, 7.19, 7.35, 7.45, 7.47, 7.78. HRMS (FAB) calcd for C25H28N2O (MH+) 373.2280, found 373.2288.

Sources & evidence

ORD record
ord-8e4648aa8ec846989eef18fc73b2a3d8
Source dataset
uspto-grants-2003_07
Patent number
US06586421B2

Reaction notes

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