HCID 22396965, compound → HCID 69895366, compound

HRID 1356380Notes

Reaction equation

HRID 1356380 reaction equation
Cl.Cl.ClC1C=CC(C2C3[C@@H]4CCNCC[C@@H]4NC=3C=CC=2)=CC=1.[Cl:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][C:32]1[C:33]2[C:34]3[CH2:45][CH2:44][NH:43][CH2:42][CH2:41][C:35]=3[NH:36][C:37]=2[CH:38]=[CH:39][CH:40]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][C:32]1[C:33]2[C@@H:34]3[CH2:45][CH2:44][NH:43][CH2:42][CH2:41][C@@H:35]3[NH:36][C:37]=2[CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 22396965HCID 22396965, compoundHCID 69896056HCID 69896056, compound

Product 1

HCID 69895366HCID 69895366, compound

Procedure

Following the procedure for the preparation of (5aS*,10bS*)-10-(4-chlorophenyl)-1,2,3,4,5,5a,6, 10b-octahydroazepino[4,5-b]indole dihydrochloride, making non-critical variations, starting from N-(2-chlorophenyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indol-10-amine the title compound was prepared: 1H NMR (DMSO-d6)δ 61.68, 1.77, 1.93, 2.58, 2.73, 2.95, 5.62, 6.20, 6.77-6.82, 6.86, 6.94, 7.14, 7.37. HRMS (FAB) calcd for C18H20ClN3 (MH+) 314.1424, found 314.1422.

Sources & evidence

ORD record
ord-8611cc51c36f499f8474fde963882f08
Source dataset
uspto-grants-2003_07
Patent number
US06586421B2

Reaction notes

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