反应详情

温度

60 °C

A suspension of methyl 4-(4-biphenylylmethoxy)phenylacetate (1000 g), N,N-dimethylethylenediamine (795 g), and 1H-1,2,4-triazole (207 g) in methanol (2.0 l) was heated under reflux under nitrogen for 10 hr and was left to stand at room temperature over night. The reaction mixture was warmed to 60±2° C. and methanol (4.0 l) was added for 35 min. After stirring under reflux for additional one hr the reaction mixture was cooled to room temperature. The precipitate was collected by filtration and washed with methanol (2.0 l) to obtain the titled compound (1109 g).

1. temperaturewas heated
2. temperatureunder reflux under nitrogen for 10 hr
3. waitwas left
4. waitto stand at room temperature over night
5. temperatureunder reflux for additional one hr the reaction mixture
6. temperaturewas cooled to room temperature
7. filtrationThe precipitate was collected by filtration
8. washwashed with methanol (2.0 l)