1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-(4-Biphenylylmethoxy)phenyl-N-[2-(N,N-dimethylamino)ethyl]acetamide

Participants

Reaction Steps

To a solution of 4-(4-biphenylylmethoxy)phenylacetic acid (0.6 g) in THF (30 ml) were added WSC (0.4 g) and HOBt (0.3 g). N,N-Dimethylethylenediamine (0.2 g) was added to the reaction mixture. After stirring at room temperature for 18 hr, the reaction mixture was poured onto water and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated in vacuo. The residue was recrystallized from ethyl acetate/ethanol to obtain the titled compound (0.3 g).

Provenance & Evidence