1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 9931616, compound

Participants

Reaction Steps

To a solution of 4-(4-biphenylylmethoxy)benzoic acid (1.008 g) in THF (20 ml)/acetonitrile (20 ml) were added WSC (0.775 g), HOBt (0.504 g), 1-(2-aminoethyl)piperidine (0.56 ml), and triethylamine (1.2 ml). After stirring at room temperature for 17 hr, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with 10% aqueous potassium carbonate and saturated aqueous sodium chloride sequentially, dried, and concentrated. The residue was recrystallized from ethyl acetate/diisopropyl ether to obtain the titled compound (0.993 g).

Provenance & Evidence