1-Pyrrolidineethanamine → HCID 9930863, compound

Participants

Reaction Steps

To a solution of 4-(4-biphenylylmethoxy)benzoic acid (1.005 g) in THF(30 ml)/acetonitrile (30 ml) were added, WSC (0.772 g), HOBt (0.516 g), 1-(2-aminoethyl)pyrrolidine (0.453 g), and triethylamine (1.2 ml). The reaction mixture was stirred at room temperature for 29 hr, diluted with water, and extracted with ethyl acetate. The organic layer was washed with 10% aqueous potassium carbonate and saturated aqueous sodium chloride sequentially, dried, and concentrated. The residue was recrystallized from ethanol/diisopropyl ether to obtain the titled compound (0.891 g).

Provenance & Evidence