HCID 18508367, compound → HCID 9930663, compound

HRID 1356472Notes

Reaction equation

HRID 1356472 reaction equation
[C:1]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([NH:18][CH2:19][CH2:20][NH:21]C(=O)OC(C)(C)C)=[O:17])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.[ClH:35].C(OCC)(=O)C>C(O)(=O)C>[ClH:35].[NH2:21][CH2:20][CH2:19][NH:18][C:16](=[O:17])[CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:4]2[CH:3]=[CH:2][C:1]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:6][CH:5]=2)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 18508367HCID 18508367, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9930663HCID 9930663, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of tert-butyl 2-(((4-([1,1′-biphenyl]-4-ylmethoxy)phenyl)acetyl)amino)ethylcarbamate (1.5 g) in acetic acid (100 ml) was added 4N hydrochloric acid/ethyl acetate (4 ml) at room temperature. After stirring at room temperature for 2 hr, the precipitate was collected by filtration, which was washed with ethyl ether and dried to obtain the titled compound (0.9 g).

Workup

  1. filtrationthe precipitate was collected by filtration, which
  2. washwas washed with ethyl ether
  3. customdried

Sources & evidence

ORD record
ord-04580bdf2b2247eb96c44d391feb24c5
Source dataset
uspto-grants-2003_07
Patent number
US06586475B1

Reaction notes

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