1-Pyrrolidineethanamine → HCID 9930863, compound

Participants

Reaction Steps

To a solution of 4-([1,1′-biphenyl]-4-ylmethoxy)benzoic acid (3 g) in THF (200 ml) were added WSC (2 g) and HOBt (1.5 g) followed by the addition of 1-(2-aminoethyl)pyrrolidine (1.1 g). After stirring at room temperature for 30 min, triethylamine (2 ml) added to the reaction mixture, which was stirred at room temperature for additional 72 hr. The reaction mixture was diluted with ethyl acetate, washed with 10% aqueous potassium carbonate and water sequentially, dried, and concentrated. The residue was recrystallized from ethanol/ethyl ether to obtain the titled compound (2.7 g).

Provenance & Evidence