HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → (2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Leucine, N-carboxy-, N-benzyl ester, L- | HCID 74840 | — |
| Reactant | N-((Phenylmethoxy)carbonyl)-L-leucyl-L-leucine | HCID 7299379 | — |
| Reactant | (1S)1-(tert-butoxycarbonyl)amino-1-(4carboethoxythiazol-2-yl)-3-methylbutane | HCID 14680168 | — |
| Product | (2S)-2-(benzyloxycarbonyl)amino-N-(4-carboethoxythiazol-2-yl)methyl-4-methylpentanamide | HCID 18396119 | — |
Reaction Steps
Following the procedure of Example 13, except substituting 1-(tert-butoxycarbonyl)amino -1-4-carboethoxythiazol-2-yl)methane for (1S)1-(tert-butoxycarbonyl)amino-1-(4carboethoxythiazol-2-yl)-3-methylbutane, and N-Cbz-L-leucine for N-Cbz-L-leucinyl-L-leucine, the title compound was prepared (0.120 g, 32%). MS (MH+): 434.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586466B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-225e59585228446e8709ea3d1989875a |
| Source note | uspto-grants-2003_07 |