HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allylamine → HCID 70008891, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allylamine | HCID 7853 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Leucine, N-carboxy-, N-benzyl ester, L- | HCID 74840 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70008891 | HCID 70008891 | — |
Reaction Steps
N-Cbz-leucine (3.0 g, 11.3 mmol) was dissolved in DMF (50 ml), then NMM (1.3 g, 12.4 mmol) was added, followed by allyl amine (0.65 g, 0.85 mmol), and HBTU (4.3 g, 11.3 mmol) and the reaction was stirred overnight at RT. The reaction was diluted with water, extracted with EtOAc, dried with magnesium sulfate, filtered, concentrated, and chromatographed (silica gel, 40% EtOAc:hexanes): MS(ES) M+H+=305.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586466B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-d534ee9a21ef47dea9b7db36c5c27d86 |
| Source note | uspto-grants-2003_07 |