Hydrochloric Acid → HCID 18509161, compound

Participants

Reaction Steps

0.20 ml (0.40 mmol) of 2N HCl is added at room temperature to a solution of 50 mg (0.13 mmol) of 2-amino-5,7-di-tert-butyl-3-(3,4-dimethoxyphenyl)-benzofurane [compound (303), Table 3, prepared according to Example 3a] in 2 ml methanol and stirred at room temperature for one hour. The reaction mixture is diluted with water and extracted three times with ethyl acetate. The organic phases are combined, dried over sodium sulfate and concentrated using a vacuum rotary evaporator. The residue yields 41 mg (82%) of 5,7-di-tert-butyl-3-(3,4-dimethoxyphenyl-3H-benzofuran-2-one (compound (103), Table 1), viscous oil.

Provenance & Evidence