Citric Acid → HCID 59075932, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 13.0 g (32.7 mmol) of the compound of Example XII in 1100 ml of a sat. solution of citric acid is stirred at 60° C. for 16 h. The mixture is allowed to cool and extracted with ethyl acetate (3×600 ml). The combined organic phases are washed with sat. NaCl solution and dried over Na2SO4, giving a yellow residue which is purified by flash filtration over 450 g silica gel 60 using EtOAc/cyclohexane 1:20 to 20:1.

Provenance & Evidence