Methanol → HCID 9841041, compound

Participants

Reaction Steps

To a 2 l of three-necked flask equipped with thermometer, pH meter and mechanical stirrer were charged distilled water (1 l), (S)-3-acetoxy-4-bromobutyric acid (90 g, 0.4 mol) and tetrabutylammonium hydroxide, 1.0 M in methanol (1.2 l, 1.2 mol). The reaction mixture was stirred at 0˜5° C. for 2 hours to afford (S)-3,4-epoxybutyric acid tetrabutyl ammonium salt. Over 99% of conversion was detected by NMR.

Provenance & Evidence