HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Methyl (3R)-4-cyano-3-hydroxybutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (R)-4-cyano-3-hydroxybutyric acid | HCID 10236005 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl (3R)-4-cyano-3-hydroxybutanoate | HCID 10149003 | 91% |
Reaction Steps
(R)-4-cyano-3-hydroxybutyric acid (1.0 mol) in methanol (500 ml) and conc. sulfuric acid (5 g) were refluxed for 5 hours. The reaction mixture was neutralized with sodium carbonate and filtered. The filtrate was concentrated in vacuo to afford (R)-4-cyano-3-hydroxybutyric acid methyl ester (130 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586616B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-88710c1f836f49869471671e60213968 |
| Source note | uspto-grants-2003_07 |