HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → HCID 69940102, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (R)-4-cyano-3-hydroxybutyric acid | HCID 10236005 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69940102 | HCID 69940102 | 92% |
Reaction Steps
Benzylalcohol (216 g, 2 eq.) and conc. sulfuric acid (5 g) were added to (R)-4-cyano-3-hydroxybutyric acid (1.0 mol) dissolved in acetonitrile (500 ml) and refluxed for 5 hours. The reaction mixture was neutralized with sodium carbonate and filtered. The filtrate was concentrated in vacuo to afford (R)-4-cyano-3-hydroxybutyric acid benzyl ester (157 g, 92%) which was purified by column chromatography on a silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06586616B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-a95b9850548541d9ae65b1bb98f31c62 |
| Source note | uspto-grants-2003_07 |