反应详情

温度

50 °C

To a suspension of 4′-fluoro-p-toluenesulfonanilide (486.6 g (1.80 mol) in acetic acid (955 ml), 97% fuming nitric acid (128.6 g (1.98 mol) was added dropwise, keeping the inner temperature at 45° C., over a period of 40 minutes. After completion of the addition, the reaction mixture was stirred at 50° C. for 2 hours and left to cool to room temperature. Water (2000 ml) was then added and the mixture was stirred for 30 minutes. The crystals separated were filtered and washed with water to give 543.5 g (97%) of 4′-fluoro-2′-nitro-p-toluenesulfonanilide as yellow crystals.

1. customat 45° C.
2. additionAfter completion of the addition
3. waitleft
4. temperatureto cool to room temperature
5. stirringthe mixture was stirred for 30 minutes
6. customThe crystals separated
7. filtrationwere filtered
8. washwashed with water