Water → HCID 18509295, compound

Participants

Reaction Steps

Methoxylamine hydrochloride (0.90 g (10.8 mmol) was suspended in pyridine (2.0 ml). To this, under cooling with ice and with stirring, a solution of 5-chloro-1,3-dimethyl-4-pyrazolesulfonyl chloride (2.29 g (10.0 mmol)) in acetonitrile (2.0 ml) was added dropwise, and the mixture was stirred under cooling with ice for one hour and at room temperature for one hour. Water (50.0 ml) was added to bring about separation of crystals. The crystals were filtered and washed with water, dried, and subjected to silica gel column chromatography with ethyl acetate-hexane (1:1) as eluent to give 1.72 g (72%) of 5-chloro-1,3-dimethyl-N-methoxy-4-pyrazolesulfonamide as white crystals.

Provenance & Evidence