HCID 18509415, compound → HCID 18509430, compound

HRID 1356818Notes

Reaction equation

HRID 1356818 reaction equation
[CH3:1][C:2]([CH3:23])([CH3:22])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([CH3:21])=[CH2:20])[CH:14]=1)[CH:9]([CH3:11])[CH3:10].[ClH:24].C(OCC)(=O)C>>[ClH:24].[CH3:23][C:2]([CH3:1])([CH3:22])[C:3]#[C:4]/[CH:5]=[CH:6]/[CH2:7][N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([CH3:21])=[CH2:20])[CH:14]=1)[CH:9]([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 18509415HCID 18509415, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18509430HCID 18509430, compoundYield 85.3%

Procedure

The procedure described in Example 12 was repeated, except that Compound 41 (1.50 g; 4.9 mmol) and 4N hydrochloric acid—ethyl acetate (1.3 ml; 5.2 mmol) were used, to thereby yield 1.43 g of the target compound (yield: 85.3%).

Sources & evidence

ORD record
ord-1692c87704b2472e9d31a0ff0abaeb40
Source dataset
uspto-grants-2003_07
Patent number
US06586633B1

Reaction notes

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