Benzene → N-Methyl-N-[4-(1-methyl-1-phenylethyl)benzyl]-(3-isopropenylbenzyl)amine

Participants

Reaction Steps

Methyl triphenyl phosphonium bromide (1.67 g; 4.68 mmol) was added to benzene (20 ml). While the mixture was stirred under nitrogen atmosphere at room temperature, n-butyl lithium in n-hexane (1.63 M: 2.9 ml; 4.73 mmol) was added dropwise. The mixture was stirred for 5 minutes, and Compound 28 (1.16 g; 3.12 mmol) in benzene (5 ml) was added dropwise thereto, followed by stirring overnight at room temperature. Reaction was stopped by pouring the mixture into ice/water, followed by extraction with benzene (100 ml).

Provenance & Evidence