HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1356930Generated: November 1, 2026
Dimethylformamide → 2-(4-Nitro-benzyl)-isoindole-1,3-dione
https://huagongshe.com/reaction/1356930
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | 4-Nitrobenzyl chloride | HCID 7482 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Nitro-benzyl)-isoindole-1,3-dione | HCID 270867 | — |
Reaction Steps
A mixture of phthalimide (4 g), p-nitrophenylmethylchloride (4,7 g), potassium carbonate (4 g) and DMF (20 ml) was stirred at 150° C. for 1.5 h. After cooling, the mixture was diluted with water. The precipitate was filtered and the crude product (I) was recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06589452B2 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-d5a40e506e1e4b02b500500ace994495 |
|---|
| Source note | uspto-grants-2003_07 |
|---|
