Diethyl Ether → HCID 12074084, compound

Participants

Reaction Conditions

Reaction Steps

Part A: 8-(2,4-dichlorophenyl)-2-ethyl-3-(1-hydroxybutyl)imidazo[1,2-a]pyrazine: The aldehyde (1.6 g, 5.0 mmol, Part D of Example 1) was dissolved in anhydrous THF (25.0 mL) and cooled to −78° C. under nitrogen. To this mixture was added dropwise 2.0 M n-PrMgCl in diethyl ether (6.7 mL, 14.4 mmol) and stirred at −78° C. for 4 h. TLC (1:10 MeOH/CH2Cl2) revealed absence of starting material spot (Rf=0.88) and showed a new spot at Rf=0.05. The reaction mixture was quenched with saturated NH4Cl (30.0 mL), stirred the mixture for 10 min., extracted with EtOAc (3×100 mL), dried (MgSO4) and concentrated in vacuum to afford yellow oil. The residue was purified by flash column chromatography on a silica gel using 2.5% MeOH/CH2Cl2 to afford 1.63 g (84%, mp 159-160° C.) of desired product as white solid.

Provenance & Evidence