HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1357000Generated: November 2, 2026
Cyclobutylamine → 2-Chloro-N-cyclobutyl-7H-purin-6-amine
https://huagongshe.com/reaction/1357000
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloropurine | HCID 5324412 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-Chloro-N-cyclobutyl-7H-purin-6-amine | HCID 15965556 | — |
Reaction Steps
Cyclobutylamine (20 g, 0.28M) and N,N-diisopropylethylamine (50.4 ml, 0.28M) is added to a suspension of 2,6-dichloropurine (48.4 g, 0.25M) in n-butanol (480 ml). The mixture is stirred at 60° C. for 20 hours. The mnixture is cooled and the precipitate isolated by filtration, washed with n-butanol and dried under vacuum to give 6cyclobutylamino-2-chloropurine;ES+ (M−1) 222.5; mp 237.8° C. dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06589950B1 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-4b6847a39908448da6d7cd8c0a19d35d |
|---|
| Source note | uspto-grants-2003_07 |
|---|
