Ethylamine → HCID 18504782, compound

HRID 1357001Notes

Reaction equation

HRID 1357001 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[CH2:12]([NH2:14])[CH3:13]>C(O)CCC>[CH2:12]([NH:14][C:4]1[N:3]=[C:2]([Cl:1])[N:10]=[C:9]2[C:5]=1[NH:6][CH:7]=[N:8]2)[CH3:13]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 53244122,6-Dichloropurine

Product 1

HCID 18504782HCID 18504782, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
84 °C

Procedure

To a suspension of 2,6-dichloropurine (2 g, 10.6 mmol) in n-butanol (3 ml), is added ethylamine (2M in THF)(15 ml). The solution is stirred at 84° C. for 2.5 hours and then cooled to ambient and stirred for a further 2 hours. The resulting precipitate is isolated by filtration, washed with n-butanol, methanol and ethyl acetate. The solid is dried at 70° C., under vacuum, for 16 hours to give 6-ethylamino-2-chloropurine; ES+ (M+1)197.5,198.2; mp 237-239° C.

Workup

  1. temperaturecooled
  2. stirringstirred for a further 2 hours
  3. customThe resulting precipitate is isolated by filtration
  4. washwashed with n-butanol, methanol and ethyl acetate
  5. customThe solid is dried at 70° C., under vacuum, for 16 hours

Sources & evidence

ORD record
ord-7114661dbbb84df2b70b984e3dfa2ee1
Source dataset
uspto-grants-2003_07
Patent number
US06589950B1

Reaction notes

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