m-Chloroperbenzoic acid → 5-Cyclopentyloxy-1-(3,5-dichloropyridin-4-ylmethyl)-6-methoxy-phthalazin-3-oxide

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Reaction Steps

A solution under stirring of 5-cyclopentyloxy-1-(3,5-dichloropyridin-4-ylmethyl)-6-methoxy-phthalazine (0.1 g, 0.741 mmoles), obtained as described in example 8, in methylene chloride (2 ml), was added with 55% m-chloroperbenzoic acid (255.75 mg, 0.816 mmoles). The mixture was diluted with methylene chloride, washed with a solution of NaHCO3, anhydrified and dried. The residue was flash chromatographed over silica gel (eluent:methylene chloride/ethyl acetate 1:1) and the eluate taken up in ether to give 0.2 g of the title product (yield: 64%).

Provenance & Evidence