Water → Oxolan-3-yl methanesulfonate

Participants

Reaction Steps

A solution of tetrahydrofuran-3-ol (4.6 g, 52.2 moles) in methylene chloride (70 ml) at 0° C. was added with triethylamine (8.36 ml, 60 moles) and mesyl chloride (4.44 ml, 57.4 moles) in methylene chloride (85 ml). The temperature was left to rise to room value and after 1 hour the mixture was poured into water and in methylene chloride. The organic phases were anhydrified and dried to give 8.12 g of the title product (yield: 93%).

Provenance & Evidence