Thionyl Chloride → 2-(Chloromethyl)-1-fluoro-3-methoxybenzene

HRID 1357024Notes

Reaction equation

HRID 1357024 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[C:3]=1[CH2:4]O.S(Cl)([Cl:14])=O>C1C=CC=CC=1>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[C:3]=1[CH2:4][Cl:14]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 27793202-Fluoro-6-methoxybenzyl alcohol

Product 1

HCID 129793072-(Chloromethyl)-1-fluoro-3-methoxybenzene

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

0.57 g (3.64 mmol) of 2-fluoro-6-methoxybenzyl alcohol was dissolved in 10 ml of benzene, and the resultant solution was added with 0.56 g (4.73 mmol) of thionyl chloride under a room temperature. The obtained solution was stirred for 1 hour at a room temperature to complete a reaction. The reacted solution was then condensed under reduced pressure to obtain a crude product of 2-fluoro-6-methoxybenzyl chloride.

Workup

  1. customa reaction
  2. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-cda0b1b4a9ab46a195ed2b5f887a82e0
Source dataset
uspto-grants-2003_07
Patent number
US06589967B1

Reaction notes

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