反应详情

On the other hand, 0.50 g (3.05 mmol) of 1-(4,6-dimethyl-2-pyridinyl)ethanone oxime was dissolved in 5 ml of N,N-dimethylformamide, and the resultant solution was added with 0.12 g (3.00 mmol) of sodium hydride (60%, oiliness) while cooling the solution with ice. The obtained solution was stirred for 30 min. at a temperature below 0° C. and subsequently added with the whole amount of the toluene solution of 2,4-dimethoxybenzyl chloride prepared previously under cooling with ice. The resultant solution was stirred for 1.5 hours while cooling with ice, and the reacted solution was then poured into icewater, and the ice water containing the reacted solution was extracted with diethyl ether. The resultant nonaqueous layer was separated and washed with water and then dried with anhydrous magnesium sulfate. The dried layer was then condensed under reduced pressure to obtain a crude product. Then, said crude product was purified by means of silica gel column chromatography (eluate; hexane:ethyl acetate=7:3 (v/v)) to obtain the target compound in an amount of 0.62 g. nD20.7; 1.5722

1. temperaturewhile cooling the solution with ice
2. customprepared previously
3. temperatureunder cooling with ice
4. temperaturewhile cooling with ice
5. additionthe reacted solution was then poured into icewater
6. extractionthe ice water containing the reacted solution was extracted with diethyl ether
7. customThe resultant nonaqueous layer was separated
8. washwashed with water
9. dry with materialdried with anhydrous magnesium sulfate
10. customcondensed under reduced pressure